Aim of the course
Immunotoxic agents can affect the immune system. This interaction may result in direct toxicity. The immune system may also react to immunotoxic agents in a specific fashion. Immune responses to these agents may then lead to indirect adverse effects. Immunotoxic agents include chemicals, genetically modified products, and radiation. Exposure can occur at the work place, in the indoor and in the outdoor environment, via food and via medicinal procedures. The aim of the course is to familiarize participants with consequenses of immunotoxicity, mechanisms of immunotoxicity, and testing for immunotoxicity.

Content of the course
The course consists of lectures, and tutorials in which case studies of various examples of immunotoxicity will be dealt with.
Subjects include:
– Immunotoxicology-related aspects of toxicology
– Immunology
– Immunotoxicology
– Immune deficiencies
– Immunosuppression
– Clinical allergy
– Immunotoxicological-aspects of allergy
– Chemical-induced autoimmunity
– Clinical autoimmunity
– Cases: silicons, hexachlorobenzene.

Outcomes (competences, skills)
On successful completion of the course, participants should:
• have knowledge of the general principles of immunotoxicology
• have knowlegde on clinical and epidemiological aspects of immunotoxicity
• have knowledge on the specific aspects of immunotoxicology, i.e. immunosuppression, allergy, and autoimmunity
• have knowledge of selected toxicants in the three areas of immunotoxicity
• have knowledge on modes of action of selected immunotoxicants
• have knowledge on regulatory aspects of immunotoxicity
• have knowledge innovative developments in immunotoxicity testing
• have knowledge on alternative test methods for identifying immunotoxicity

J.W. Cohen-Tervaert, L. van de Corput
E. van Hoffen, H. van Loveren
A.H. Penninks, R. Pieters
R. de Weger

Coordinator: Dr. J. Ezendam; Dr. R.H.H. Pieters
Duration: 4 days
ECTS credits: 1.5
Number of participants: 10-22
Period:     for exact dates, please consult the current programme schedule
Fee:          see tuition fees (includes reduced fees for PhD students)
Location: Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht

For registration please proceed to the PET application form and for questions please contact the PET Office

Last updated: 30-Mar-17