Introduction

 

 


Course: General Toxicology

 

Aim of the course

 

The aim of the course is twofold. In the first place, it offers participants seeking vocational training but lacking formal undergraduate training in toxicology the opportunity to obtain extensive, basic theoretical knowledge in this field. This basic knowledge is necessary to successfully complete the other, more specialized modules of the programme. Secondly, this module can serve as a refresher course for PhD students and others who intend to take only some of the other programme modules.

This introductory course will therefore ensure that in the end all PET students will have the same basic knowledge of toxicology.

 

Content of the course

 

The course consists of twenty three lectures on various subjects, given by experts in those subjects. These subjects relate to most of the chapters in the textbook "Toxicology: Principles & Applications", developed by Eurotox and the Open University. The lectures are intended to help participants to become acquainted with the most important toxicological issues. The book is not obliged, but recommended and will be made available to partici­pants at cost price. The course is only offered by a CD-ROM for self-study.

 

Examination

 

Participants will be examined after appointment with the coordinator. The examination will consist of ten open questions formulated by the lecturers and will take place in Wageningen.

 

Module outcomes (competences, skills)

 

On successful completion of the module, participants should:

·         have acquired basic knowledge and understanding of the general principles of toxicology

·         have acquired basic insight in the application of toxicology in hazard and risk assessment

 

List of subjects

 

- Introduction

- Qualitative and quantitative exposure

- Uptake, distribution and elimination

- Biotransformation

- Quantitative kinetics

- Dose-response, SAR, and combination toxicology

- Toxicity testing

- Cytopathology and cytotoxicity

- Genetic toxicology

- Chemical carcinogenesis and oncogenes

- Regulatory toxicology

- Hepatotoxicology

- Nephrotoxicology

- Dermal toxicology

- Reproduction toxicology

- Immunotoxicology

- Toxicology of the heart and blood

- Respiratory toxicology

- Toxicology of the endocrine system

- Neurotoxicology

 

List of lecturers

Dr G.M. Alink                                        Dr A.H. Penninks

Dr R.A. Baan                                         Dr A.H. Piersma

Prof Dr A. Bast                                     Dr R.H.H. Pieters

Dr P.J.A. Borm                                     Mrs Prof Dr I.M.C.M. Rietjens

Dr A. Brouwer                                       Dr J.J.M. van de Sandt

Prof Dr V.J. Feron                                 Dr J.H.M. Temmink

Dr J.P. Groten                                       Drs H.J.M. Verhaar

Prof Dr J.H. Koeman                             Prof Dr E.W. Vogel

Prof Dr J. Noordhoek                            Dr H.P.M. Vijverberg

                                                                       

Duration:          ?

 

ECTS credits:   3

 

Period:             Lectures by CD-Rom (examination after consultation)

 

Fee:                  € 1,500.- (excl. € 150.- for Eurotox/OU book) (PhD students may apply for the reduced rate of € 200.=)

 

Location:          Wageningen University

                        Department of Toxicology

                        Tuinlaan 5, De Dreijen

                        Wageningen, The Netherlands