Course: Molecular Toxicology
Aim of the course
This module is focussed on understanding mechanisms
of toxicity on the molecular level.
Content of the course
In
a number of lectures and case-studies, molecular mechanisms underlying (organ-selective)
toxicity and carcinogenicity will be discussed. Special emphasis will be on the
role of drug metabolism and bio(in)activation in toxicology. Topics include: multiplicity and properties
of drug-metabolising enzymes (cytochrome P450, glutathione S-transferases and
others); experimental approaches to characterize enzymes involved in drug
metabolism; clinical and toxicological consequences of genetic polymorphisms of
drug metabolising enzymes; chemical and biological properties of reactive intermediates
responsible for toxicity; mechanisms underlying idiosyncratic drug reactions;
novel computational approaches to predict drug metabolism and toxicity; and,
mechanisms determining organ-selective toxicity.
Examination
At
the end of the week (Friday afternoon), the participants will give an oral
presentation on the theoretical assignments, which will subsequently be
discussed.
Co-ordinators
Dr.
J.N.M.
Duration: 1 week
ECTS credits: 1.5
Period: 22/03 - 26/03, 2010
Fee: € 1,000 (PhD students may apply for the reduced rate of €
250.=)
Location: