Course: Risk
Assessment
Aim of the course:
Toxicological risk
assessment is the process of estimating the qualitative and quantitative health
risks posed to man and the environment by the use of chemicals. The aim of this
course is to familiarise participants with the general procedures followed
during a toxicological risk assessment. Emphasis will be laid on the
identification of hazards and risk posed to humans and the environment.
Furthermore, attention will be paid to problems typical of various categories
of chemical substances. The working format of the course is a mixture of
self-study aided by lectures presented on CD-ROM, classroom lectures and
tutorials and computer-aided practicals.
Content of the course and format:
The course consists
of lectures and tutorials during which the consecutive steps of a risk
assessment will be dealt with.
A number of the
lectures are available on CD-ROM and are meant for self-study, in
advance of the classroom meetings. Subjects included are the various toxicity
tests, their endpoints and hierarchy, critical effects and uncertainty factors,
and the calculation of health-based guidance values. Furthermore, specific
problems created by carcinogens and other types of chemicals will be treated.
During the classroom
meetings, a number of specific groups of chemicals and practical situations
will be dealt with, such as medicines, industrial chemicals, household
chemicals, crop protection agents and food additives. Here too, health effects for
humans as well as for the environment will be treated. Participants will handle
and present a specific case study.
Further
study material:
"Risk Assessment of Chemicals: An
Introduction" by C.J. van Leeuwen and J.L.M. Hermens (eds), Kluwer
Academic Publishers,
Although the lectures do not exactly follow the chapters of this book, it is recommended to purchase it as a general support for the course.
Module outcomes (competences, skills)
On successful
completion of the module, participants should:
·
have
acquired general knowledge and understanding of the methods and procedures used
in environmental and human health risk assessment and the interpretation of
toxicological data that form the basis of a risk assessment.
·
have
acquired insight in how to perform risk assessments in specific areas of
chemical applications.
·
have
hands-on experience with computer models for estimating exposure and risk
·
have
shown to be able to handle a case study on a risk assessment and to communicate
this to fellow-participants.
Examination:
There will be no
examination. Instead, participants will be required to actively take part in
the discussions during the course. They will also be judged on the handling and
presentation of a case study.
List of subjects:
A: on the CD-ROM:
Introduction
Exposure routes to
man
Exposure routes in
the environment
Toxicity tests for
human effects and their endpoints
In vitro testing for
human health
Toxicity testing for
environmental effects and their endpoints
Estimation methods:
the use of QSARs in environmental risk assessment
Risk assessment of
chemical in relation to human health
Risk assessment of
genotoxic carcinogens in relation to human health
Risk assessment of
non-genotoxic carcinogens
Toxicological risk
assessment for the environment
B: classroom meetings
Tutorial
on the general aspects of risk assessment
Practical: Risk
assessment in the environment
Practical: Specific aspects of crop protection agents
Practical: Specific aspects of industrial chemicals
Practical: Specific aspects of food, food components and food additives
Practical: Specific aspects of drugs
Practical: Specific aspects of cosmetics
Practical: Specific aspects of household chemicals
Computer practicals:
EUSIS and CONSEXPO
Case studies on
specific chemicals
List of lecturers:
On the CD-ROM:
Prof
M van den Berg
Dr
B.J. Blaauboer
Dr
J.L.M. Hermens
Dr
D. Jonker
Prof
R. Kroes
Prof
C.J van Leeuwen
Dr
M. J. Zeilmaker
Classroom
meetings:
Drs
Ing J. Bakker
Dr L.
Heijink
Dr
I.T.M. Becks
Dr
B.J. Blaauboer
Drs
W. ter Burg
Drs
J.E. Delmaar
Prof
Dr A.J. Hendriks
Dr
M. Heneweer
Dr
G. Houben
Dr
A.B.K. Jespers
Prof
Dr A.J. Murk
Dr
G. Stijntjes
Dr
R. Taalman
Ir
P.G.P.C. Zweers
Duration: One week self-study (at home/work),
one week presence in classroom meetings (3 ECTS)
ECTS credits: 3
Period: 19 - 23 October, 2009
Fee: € 2,000.-, (PhD students may apply for the reduced
rate of € 500.-)
Fee includes the CD_ROM.
The recommended book (see above) is no longer
available for a special price. Please contact your book shop.
Location: Department of Toxicology, Wageningen
University
Note
For
each Food Toxicology and Risk Assessment course, ILSI Europe provides a course
grant for applicants from CEE, SEE and Baltic countries (Albania, Bosnia and
Herzegovina, Bulgaria, Croatia, Czech Republic, Estonia, Greece, Hungary,
Latvia, Lithuania, Montenegro, Poland, Romania, Serbia, Slovakia, Slovenia, The
former Yugoslav Republic of Macedonia, Turkey). For details on conditions and
application etc, see: http://europe.ilsi.org/events/upcoming/PEtsponsor.htm